GAE: A Minimally-Invasive Option For Knee Pain From Osteoarthritis.
What is GAE?
Genicular Artery Embolization (GAE) is a cutting-edge, nonsurgical procedure that targets tiny blood vessels around the knee that drive inflammation in osteoarthritis (OA). Using just a pin-sized opening in the skin, an interventional radiologist guides a small catheter into the knee’s arteries and releases microscopic particles to reduce inflammation and pain, helping patients regain function without removing tissue or replacing the joint.
Why Patients Choose GAE
- Minimally invasive – no large incisions, performed with light sedation.
- Outpatient – most patients return home the same day.
- Targets inflammation – addresses the root driver of OA pain.
- Keeps options open – does not interfere with future treatments, including knee replacement.
Who May Benefit?
GAE is for adults with knee osteoarthritis pain who have not found relief with medications, injections, or physical therapy, and who prefer to avoid or delay knee surgery.
What to Expect
- A tiny catheter is inserted, usually through the wrist or groin.
- X-ray guidance maps the knee’s blood supply.
- Microparticles are delivered to inflamed areas.
- Patients typically go home the same day and resume light activities quickly.
How Well Does GAE Work?
Clinical studies, including randomized controlled trials, show that GAE can significantly reduce pain and improve function in patients with mild-to-moderate OA. Patients report meaningful improvement in pain scores, daily activity, and quality of life. Research also shows a favorable safety profile.
Safety
GAE has a very low rate of major complications. Most side effects, if they occur, are temporary, such as mild skin warmth or brief discomfort. Importantly, GAE does not increase risk if a knee replacement is required later.
Research Highlights
- Bagla S, et al. – Multicenter randomized sham-controlled trial demonstrated significant improvements with GAE.
- Taslakian B, et al. – Systematic review confirmed GAE is safe and effective.
- Brown JM, et al. – Technical review highlighting durable results and low complication rates.
This blog post is for educational purposes only and does not replace medical advice. Please consult your physician to determine if GAE is right for you.
Ready to learn more about Genicular Artery Embolization? Contact New England Endovascular Center today to speak with our specialists and find out if this treatment is right for you.